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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hdac4tm2.1Eno
targeted mutation 1, Eric N Olson
MGI:4418117
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hdac4tm2.1Eno/Hdac4tm2.1Eno involves: 129S/SvEv MGI:4418165
cn2
 		Hdac4tm1Eno/Hdac4tm2.1Eno
Hdac5tm1Eno/Hdac5tm1Eno
Tg(Myog-cre)1Eno/0 		involves: 129 * 129S/SvEv * 129S2/SvPas MGI:4418137
cn3
 		Hdac4tm2.1Eno/Hdac4tm2.1Eno
Tg(Myog-cre)1Eno/0 		involves: 129S/SvEv MGI:4418186


Genotype
MGI:4418165
hm1
Allelic
Composition		 Hdac4tm2.1Eno/Hdac4tm2.1Eno
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4tm2.1Eno mutation (0 available); any Hdac4 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
muscle phenotype ( J:127416 )
N
• no change in the abundance of slow fibers




Genotype
MGI:4418137
cn2
Allelic
Composition		 Hdac4tm1Eno/Hdac4tm2.1Eno
Hdac5tm1Eno/Hdac5tm1Eno
Tg(Myog-cre)1Eno/0
Genetic
Background		 involves: 129 * 129S/SvEv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4tm1Eno mutation (0 available); any Hdac4 mutation (112 available)
Hdac4tm2.1Eno mutation (0 available); any Hdac4 mutation (112 available)
Hdac5tm1Eno mutation (0 available); any Hdac5 mutation (57 available)
Tg(Myog-cre)1Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal skeletal muscle fiber type ratio ( J:127416 )
• soleus muscles show an increase in the percentage of slow myofibers




Genotype
MGI:4418186
cn3
Allelic
Composition		 Hdac4tm2.1Eno/Hdac4tm2.1Eno
Tg(Myog-cre)1Eno/0
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4tm2.1Eno mutation (0 available); any Hdac4 mutation (112 available)
Tg(Myog-cre)1Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor nerve collateral sprouting ( J:155806 )
• reinnervation occurs more rapidly compared to controls after nerve crush or cut
• however, in the absence of injury no defects in neuromuscular junctions are detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory