Phenotypes associated with this allele

• Allele Symbol: Lfng^tm1.2Egan
• Allele Name: targeted mutation 1.2, Sean E Egan
• Allele ID: MGI:4418228
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lfng^tm1.2Egan/Lfng^tm1.2Egan	FVB.129-Lfng^tm1.2Egan	MGI:4418248
hm2	Lfng^tm1.2Egan/Lfng^tm1.2Egan	involves: 129 * 129S4/SvJaeSor * FVB/N	MGI:4418247

Genotype
MGI:4418248

hm1

• Allelic Composition: Lfng^tm1.2Egan/Lfng^tm1.2Egan
• Genetic Background: FVB.129-Lfng^tm1.2Egan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung vasculature morphology ( J:155893 )

• mice exhibit reduced lung vascular branching compared to in wild-type mice

abnormal lung development ( J:155893 )

• Background Sensitivity: abnormal lung development is more severe on an FVB background

• mice exhibit altered lung patterning and reduced lung vascular branching compared to in wild-type mice

• at E16.5, saccule expansion is delayed compared to in wild-type mice

• at E18.5, saccules are less opened than in wild-type mice

• in late embryogenesis, myofibroblast progenitors in the lungs exhibit defective differentiation marked by sma+ expression compared to in wild-type mice

• however, myofibroblast progenitor cell specification and spreading in the lungs are normal

abnormal pulmonary alveolus morphology ( J:155893 )

• mice exhibit thickened alveolar walls, lack of alveolar septation, and large alveolar size compared with wild-type mice

skeleton

abnormal rib development ( J:155893 )

• rib patterning is abnormal

limbs/digits/tail

short tail ( J:155893 )

cardiovascular system

abnormal lung vasculature morphology ( J:155893 )

• mice exhibit reduced lung vascular branching compared to in wild-type mice

Genotype
MGI:4418247

hm2

• Allelic Composition: Lfng^tm1.2Egan/Lfng^tm1.2Egan
• Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

mortality/aging

prenatal lethality, incomplete penetrance ( J:155893 )

• fewer than expected mice are born

respiratory system

abnormal lung development ( J:155893 )

• Background Sensitivity: abnormal lung development is more severe on an FVB background

impaired lung alveolus development ( J:155893 )

• mice exhibit similar alveolar development defects as in Lfng^tm1Grid homozygotes

embryo

abnormal somite development ( J:155893 )

• mice exhibit similar somite patterning defect as in Lfng^tm1Grid homozygotes