Analysis Tools|
Allele Symbol Allele Name Allele ID |
Phox2btm3.1Jbr targeted mutation 3.1, Jean-Francois Brunet MGI:4418265 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fails to form, on six sides out of eight, in four embryos
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• missing, on five sides out of six, in three embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 1 week after birth, few mice are still alive
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• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
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• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice
• rhythmic phrenic discharges are less frequent than in wild-type mice
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice
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• surviving mice are smaller than wild-type mice
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• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at E13.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 1 week after birth, mice are dead
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• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
|
|
• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice
• rhythmic phrenic discharges are less frequent than in wild-type mice
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice
|
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• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• absence of all head parasympathetic ganglia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite the absence of visceral or branchial motoneurons, the main trunk of the facial nerve is present
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• visceromotor neurons are not produced
• absence of visceral or branchial motoneurons
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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