Analysis Tools|
Allele Symbol Allele Name Allele ID |
Phox2btm4Jbr targeted mutation 4, Jean-Francois Brunet MGI:4418298 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• massive depletion of retrotrapezoid nucleus neurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• the great majority of mice survive to adulthood
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• massive depletion of retrotrapezoid nucleus neurons at P9
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• frequency of rhythmic phrenic discharges is reduced and does not respond to acidification
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• hypoxic response is more vigorous (increase in ventilation is more pronounced and lasts longer) compared to controls
• exposure to pure O2 triggers periodic breathing in mutants but not in controls
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• in normoxia mean ventilation is reduced due to longer breath duration
• complete absence of normal response to hypercapnia at P2 and P9
• at 3 weeks and 4 months of age mice display a reduced increase in ventilation in response to hypercapnia
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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