All Phenotypes Adam8<tm1.1Mdz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adam8^tm1.1Mdz
targeted mutation 1.1, Marc D Zack
MGI:4418309

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam8^tm1.1Mdz/Adam8^tm1.1Mdz	DBA/1LacJ-Adam8^tm1.1Mdz	MGI:4418310

Allelic Composition	Adam8^tm1.1Mdz/Adam8^tm1.1Mdz
Genetic Background	DBA/1LacJ-Adam8^tm1.1Mdz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam8^tm1.1Mdz mutation (0 available); any Adam8 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:155243 )

N	• normal response to lipopolysaccheride challenge

• incidence and severity of lipopolysaccharide-synchronized collagen-induced arthritis are significantly reduced

• inflammation and cartilage degradation are significantly less severe

• less severe synovial inflammation and cartilage erosion

skeleton

• incidence and severity of lipopolysaccharide-synchronized collagen-induced arthritis are significantly reduced

• inflammation and cartilage degradation are significantly less severe

• less severe synovial inflammation and cartilage erosion

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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