Phenotypes associated with this allele

• Allele Symbol: Kcnh3^tm1Akmi
• Allele Name: targeted mutation 1, Akira Miyake
• Allele ID: MGI:4418359
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnh3^tm1Akmi/Kcnh3^tm1Akmi	involves: 129S4/SvJae * C57BL/6	MGI:4418452
ht2	Kcnh3^tm1Akmi/Kcnh3^+	involves: 129S4/SvJae * C57BL/6	MGI:4418453

Genotype
MGI:4418452

hm1

• Allelic Composition: Kcnh3^tm1Akmi/Kcnh3^tm1Akmi
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal long-term object recognition memory ( J:155749 )

• enhanced latent learning in a water finding task

• reduced finding latency

abnormal spatial reference memory ( J:155749 )

• enhanced spatial reference memory

• more time spent in the target quadrant of a water maze

abnormal spatial working memory ( J:155749 )

• enhanced working memory

• higher rate of alternation between arms and fewer entries when tested in a "Y" maze

nervous system

abnormal CNS synaptic transmission ( J:155749 )

• reduced accommodation in CA1 neurons to action potential trains induced by strong polarizing currents

abnormal long-term potentiation ( J:155749 )

• long term potentiation induced in Shaffer collaterals-CA1 synapses

Genotype
MGI:4418453

ht2

• Allelic Composition: Kcnh3^tm1Akmi/Kcnh3⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

behavior/neurological

abnormal long-term object recognition memory ( J:155749 )

• enhanced latent learning in a water finding task

• reduced finding latency

abnormal spatial reference memory ( J:155749 )

• enhanced spatial reference memory

• more time spent in the target quadrant of a water maze