Phenotypes associated with this allele

• Allele Symbol: Ntsr1^tm2Pang
• Allele Name: targeted mutation 2, Zhen Pang
• Allele ID: MGI:4418470
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntsr1^tm2Pang/Ntsr1^tm2Pang	involves: 129P2/OlaHsd * C57BL/6J	MGI:4418497

Genotype
MGI:4418497

hm1

• Allelic Composition: Ntsr1^tm2Pang/Ntsr1^tm2Pang
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal body temperature homeostasis ( J:155994 )

• maintain a normal body temperature in response to NT-2 and NT69L (neurotensin agonists) unlike controls which become hypothermic

behavior/neurological

increased vertical activity ( J:155994 )

• neurotensin agonists fail to reduce spontaneous climbing behavior

• neurotensin agonists fail to reduce climbing in response to apomorphine

abnormal thermal nociception ( J:155994 )

• neurotensin agonists fail to increase the latency of response to thermal stimulus in a tail immersion test