Phenotypes associated with this allele

• Allele Symbol: Ehmt2^tm1.1Tara
• Allele Name: targeted mutation 1.1, Alexander Tarakhovsky
• Allele ID: MGI:4418499
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Drd2-cre)ER44Gsat/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4418569
cn2	Ehmt1^tm1.1Tara/Ehmt1^tm1.1Tara Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Camk2a-cre)2Gsc/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4418570
cn3	Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Camk2a-cre)2Gsc/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4418567
cn4	Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Drd1-cre)EY262Gsat/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4418568

Genotype
MGI:4418569

cn1

• Allelic Composition: Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara; Tg(Drd2-cre)ER44Gsat/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron physiology ( J:155739 )

• small significant negative gain in excitability of medium spiny neurons

behavior/neurological

enhanced behavioral response to xenobiotic ( J:155739 )

• greater increase in locomotor and exploratory behaviors in response to caffeine, a repressor of Drd2.

induced hyperactivity ( J:155739 )

• greater increase in locomotor and exploratory behaviors in response by to caffeine, a repressor of Drd2

Genotype
MGI:4418570

cn2

• Allelic Composition: Ehmt1^tm1.1Tara/Ehmt1^tm1.1Tara; Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara; Tg(Camk2a-cre)2Gsc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

behavior/neurological

decreased exploration in new environment ( J:155739 )

• travel significantly less than control mice in a new environment

decreased vertical activity ( J:155739 )

• reduction in vertical episodes in a new environment

decreased locomotor activity ( J:155739 )

• travel significantly less than control mice in a new environment

Genotype
MGI:4418567

cn3

• Allelic Composition: Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara; Tg(Camk2a-cre)2Gsc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

nervous system

nervous system phenotype ( J:155739 )

N • the specific neuronal cell architecture in the striatum and the hippocampus was not altered

behavior/neurological

impaired behavioral response to xenobiotic ( J:155739 )

• almost completely lack a preference for sucrose

decreased exploration in new environment ( J:155739 )

• starting around 6-8 weeks of age, in an open field make fewer total arm entries in an elevated plus maze

abnormal liquid preference ( J:155739 )

• almost completely lack a preference for sucrose

decreased anxiety-related response ( J:155739 )

• make more entries into and spend more time in open arms in an elevated plus maze

decreased vertical activity ( J:155739 )

• in a new environment

decreased locomotor activity ( J:155739 )

• in a new environment

growth/size/body

obese ( J:155739 )

• almost doubled their body weight as compared to controls by 5-6 months of age

Genotype
MGI:4418568

cn4

• Allelic Composition: Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara; Tg(Drd1-cre)EY262Gsat/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

behavior/neurological

impaired behavioral response to xenobiotic ( J:155739 )

• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses

decreased locomotor activity ( J:155739 )

• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses

nervous system

nervous system phenotype ( J:155739 )

N • no major impact on regulation of neuronal morphology and basal electrophysiological features of Drd2-expressing MSNs in the striatum