Phenotypes associated with this allele

• Allele Symbol: Enpp2^tm1Mmas
• Allele Name: targeted mutation 1, Masayuki Masu
• Allele ID: MGI:4418729
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Enpp2^tm1Mmas/Enpp2^tm1Mmas	involves: 129P2/OlaHsd * C57BL/6N	MGI:4418730

Genotype
MGI:4418730

hm1

• Allelic Composition: Enpp2^tm1Mmas/Enpp2^tm1Mmas
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size, absence of embryo turning and angiogenic defects in the yolk sack of Enpp2^tm1Mmas/Enpp2^tm1Mmas embryos

growth/size/body

decreased embryo size ( J:156013 )

• embryos are much smaller at E9.5

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:156013 )

• at E9.5

embryo

abnormal vitelline vasculature morphology ( J:156013 )

• angiogenic defects

• large vitelline vessels do not form in the yolk sac, in which red blood cells precipitate

failure of initiation of embryo turning ( J:156013 )

• most embryos do not undergo embryonic turning

decreased embryo size ( J:156013 )

• embryos are much smaller at E9.5

abnormal visceral yolk sac endoderm morphology ( J:156013 )

• visceral endoderm cells contain many small punctate vesicles compared to few large IgG containing vesicles in wild-type controls

• lysosomes are smaller and more numerous in visceral endoderm cells

• the amount of polymerized actin is reduced at E8.5 in yolk sac visceral endoderm cells

abnormal visceral endoderm morphology ( J:156013 )

• yolk sac visceral endoderm cells contain many small punctate vesicles compared to few large IgG containing vesicles in wild-type controls

• lysosomes are smaller and more numerous in yolk sac visceral endoderm cells

• the amount of polymerized actin is reduced at E8.5 in yolk sac visceral endoderm cells

cardiovascular system

abnormal vitelline vasculature morphology ( J:156013 )

• angiogenic defects

• large vitelline vessels do not form in the yolk sac, in which red blood cells precipitate