About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox17tm2.1(icre)Heli
targeted mutation 2.1, Heiko Lickert
MGI:4418897
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox17tm2.1(icre)Heli/Sox17tm2.1(icre)Heli involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4418909
cn2
 		NipblGt(EUCE313f02)1.1Hmgu/Nipbl+
Sox17tm2.1(icre)Heli/Sox17+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CD-1 MGI:7492228
cn3
 		NipblGt(EUCE313f02)Hmgu/Nipbl+
Sox17tm2.1(icre)Heli/Sox17+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CD-1 MGI:7492242


Genotype
MGI:4418909
hm1
Allelic
Composition		 Sox17tm2.1(icre)Heli/Sox17tm2.1(icre)Heli
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm2.1(icre)Heli mutation (0 available); any Sox17 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:155991 )
• homozygotes are viable and fertile




Genotype
MGI:7492228
cn2
Allelic
Composition		 NipblGt(EUCE313f02)1.1Hmgu/Nipbl+
Sox17tm2.1(icre)Heli/Sox17+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)1.1Hmgu mutation (0 available); any Nipbl mutation (124 available)
Sox17tm2.1(icre)Heli mutation (0 available); any Sox17 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:236978 )
• heart size is similar to wild-type
atrial septal defect ( J:236978 )
• in 26% of hearts at E17.5

growth/size/body
growth/size/body region phenotype ( J:236978 )
• body size is similar to wild-type




Genotype
MGI:7492242
cn3
Allelic
Composition		 NipblGt(EUCE313f02)Hmgu/Nipbl+
Sox17tm2.1(icre)Heli/Sox17+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NipblGt(EUCE313f02)Hmgu mutation (0 available); any Nipbl mutation (124 available)
Sox17tm2.1(icre)Heli mutation (0 available); any Sox17 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:236978 )
• 5% of hearts show an atrial septal defect, statistically indistinguishable from wild-type
small heart ( J:236978 )
• correlates to body size

growth/size/body
decreased body size ( J:236978 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory