Phenotypes associated with this allele

• Allele Symbol: Tmod4^{tm1(KOMP)Wtsi}
• Allele Name: targeted mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:4419118
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmod4^tm1(KOMP)Wtsi/Tmod4^tm1(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5824343

Genotype
MGI:5824343

hm1

• Allelic Composition: Tmod4^{tm1(KOMP)Wtsi}/Tmod4^{tm1(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0400_4_E05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:236433 )

• mice are viable, fertile, and exhibit no overt myopathy and normal thin filament lengths, myofibril organization, and skeletal muscle contractile function due to compensatory upregulation of Tmod1 in neonatal skeletal muscle, along with an Lmod isoform switch wherein Lmod3 is downregulated and Lmod2 is upregulated