Phenotypes associated with this allele

• Allele Symbol: Coro2b^{tm1(KOMP)Wtsi}
• Allele Name: targeted mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:4419137
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Coro2b^tm1(KOMP)Wtsi/Coro2b^tm1(KOMP)Wtsi	C57BL/6-Coro2b^tm1(KOMP)Wtsi	MGI:6140204

Genotype
MGI:6140204

hm1

• Allelic Composition: Coro2b^{tm1(KOMP)Wtsi}/Coro2b^{tm1(KOMP)Wtsi}
• Genetic Background: C57BL/6-Coro2b^{tm1(KOMP)Wtsi}
• Cell Lines: EPD0392_7_C01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:254431 )

N • albumin to creatinine ratio in spot urine samples

N • glomerular morphology

abnormal urine protein level ( J:254431 )

• reduced proteinuria when subjected Doxorubicin-induced focal segmental glomerulosclerosis (FSGS) for 3 or 5 weeks, compared to wild-type

abnormal renal glomerulus morphology ( J:254431 )

• protection from damage when subjected Doxorubicin-induced focal segmental glomerulosclerosis (FSGS) for 3 or 5 weeks, compared to wild-type

cellular

abnormal cell adhesion ( J:254431 )

• increased average focal adhesion size on isolated mouse embryo fibroblasts (MEFs)

• average number of focal adhesion sites on isolated mouse embryo fibroblasts (MEFs) average number of focal adhesion sites on isolated mouse embryo fibroblasts (MEFs)

homeostasis/metabolism

abnormal urine protein level ( J:254431 )

• reduced proteinuria when subjected Doxorubicin-induced focal segmental glomerulosclerosis (FSGS) for 3 or 5 weeks, compared to wild-type

mortality/aging

mortality/aging ( J:254431 )

N • mice born at expected Mendelian ratio, are viable and have a normal life span

reproductive system

reproductive system phenotype ( J:254431 )

N • fertile