Phenotypes associated with this allele

• Allele Symbol: Ciart^{tm1e(KOMP)Wtsi}
• Allele Name: targeted mutation 1e, Wellcome Trust Sanger Institute
• Allele ID: MGI:4419228
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ciart^tm1e(KOMP)Wtsi/Ciart^tm1e(KOMP)Wtsi	involves: C57BL/6N	MGI:5562895
cx2	Ciart^tm1e(KOMP)Wtsi/Ciart^tm1e(KOMP)Wtsi Cry1^tm1Asn/Cry1^tm1Asn	involves: 129P2/OlaHsd * C57BL/6N	MGI:5562905

Genotype
MGI:5562895

hm1

• Allelic Composition: Ciart^{tm1e(KOMP)Wtsi}/Ciart^{tm1e(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:205586 )

N • born at expected Mendelian ratio

behavior/neurological

behavior/neurological phenotype ( J:205586 )

N • no detectable difference in behavioral rhythmicity when tested with wheel-running activity in constant darkness for a week

homeostasis/metabolism

abnormal homeostasis ( J:205586 )

• expression of circadian genes persists longer in mouse liver between ZT10 and ZT14

Genotype
MGI:5562905

cx2

• Allelic Composition: Ciart^{tm1e(KOMP)Wtsi}/Ciart^{tm1e(KOMP)Wtsi}; Cry1^tm1Asn/Cry1^tm1Asn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

homeostasis/metabolism

abnormal homeostasis ( J:205586 )

• significant phase delay (2-4 hours) of circadian gene expression