Phenotypes associated with this allele

• Allele Symbol: Naaa^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4419604
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Naaa^tm1a(KOMP)Wtsi/Naaa^tm1a(KOMP)Wtsi	B6NTac;B6N-A^tm1Brd Naaa^tm1a(KOMP)Wtsi/WtsiH	MGI:7790954
hm2	Naaa^tm1a(KOMP)Wtsi/Naaa^tm1a(KOMP)Wtsi	C57BL/6N-Naaa^tm1a(KOMP)Wtsi/Wtsi	MGI:5631331

Genotype
MGI:7790954

hm1

• Allelic Composition: Naaa^{tm1a(KOMP)Wtsi}/Naaa^{tm1a(KOMP)Wtsi}
• Genetic Background: B6NTac;B6N-A^tm1Brd Naaa^{tm1a(KOMP)Wtsi}/WtsiH
• Cell Lines: EPD0365_3_A02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to type IV hypersensitivity reaction ( J:258438 )

• in a model of 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis, DNFB-sensitized and challenged mice show increased levels of palmitoylethanolamide [PEA, an endogenous peroxisome proliferator activated receptor alpha (PPARA) agonist with analgesic and anti-inflammatory activity] in ear tissue and a markedly lower inflammatory response with significantly less DNFB-induced ear edema and scratching behavior relative to DNFB-treated wild-type controls

• however, oleoylethanolamide (OEA) levels are unaffected by DNFB treatment

integument

decreased pruritus ( J:258438 )

• mice fail to develop significant hind paw scratching behavior after DNFB challenge

Genotype
MGI:5631331

hm2

• Allelic Composition: Naaa^{tm1a(KOMP)Wtsi}/Naaa^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Naaa^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0365_3_A02

Data Sources

IMPC Data for Naaa

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

♀

IMPC - WTSI

decreased hematocrit ( J:211773 )

♀

IMPC - WTSI

decreased hemoglobin content ( J:211773 )

♀

IMPC - WTSI

homeostasis/metabolism

increased circulating iron level ( J:211773 )

♀

IMPC - WTSI