Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tubb4atm1(KOMP)Wtsi targeted mutation 1, Wellcome Trust Sanger Institute MGI:4419785 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit a normal lifespan
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| N |
• mice do not develop tremulous motor phenotypes or ataxia at advanced age and show no differences in rotarod performance or grip strength up to 1 year
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice survive up to approximately 14 weeks
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• motor defects
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• mice show progressive degeneration of granule cell neurons such that the inner granule layer is largely devoid of granule cell neurons at P48
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• P95 mice have severely atrophic cerebellum with the inner granule layer largely devoid of granule cell neurons at P48
• however, cerebellar phenotypes are less severe than in homozygous Tubb4aJit mice
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• reduction in white matter tracts such as corpus callosum, anterior commissures, and striatal fascicles at P95
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• mice show progressive degeneration of myelin with reduced myelin at P48 and P95, however reduction in myelin is not as severe as in in homozygous Tubb4aJit mice
• cerebellum is severely demyelinated at P95
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severe truncation of cilia on multi-ciliated cells although occasional longer cilia are seen
• no cilia display the symmetric 9 microtuble doublet axonemes, all show the presence of singlets
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• severe truncation of cilia on multi-ciliated cells although occasional longer cilia are seen
• no cilia display the symmetric 9 microtuble doublet axonemes, all show the presence of singlets
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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