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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pip4p1tm1(KOMP)Wtsi
targeted mutation 1, Wellcome Trust Sanger Institute
MGI:4419980
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pip4p1tm1(KOMP)Wtsi/Pip4p1tm1(KOMP)Wtsi involves: C57BL/6N MGI:6358638


Genotype
MGI:6358638
hm1
Allelic
Composition
Pip4p1tm1(KOMP)Wtsi/Pip4p1tm1(KOMP)Wtsi
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pip4p1tm1(KOMP)Wtsi mutation (0 available); any Pip4p1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• although most homozygotes appear normal at E8.5, they exhibit growth retardation/arrest at E9.5

cellular
• activation of mTORC1 (mammalian/mechanistic target of rapamycin complex 1) in response to amino acids is attenuated in mutant mouse embryonic fibroblasts relative to wild-type cells, as showed by a reduced level of S6K phosphorylation
• the extent of colocalization of Lamp1 and mTOR induced by stimulation with amino acids is less pronounced than in wild-type cells
• expression of HA-TMEM55B in mutant cells partially restores the amino acid-induced recruitment of mTOR to lysosomes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory