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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fam13atm2a(KOMP)Wtsi
targeted mutation 2a, Wellcome Trust Sanger Institute
MGI:4420095
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fam13atm2a(KOMP)Wtsi/Fam13atm2a(KOMP)Wtsi involves: C57BL/6J * C57BL/6N MGI:6196515


Genotype
MGI:6196515
hm1
Allelic
Composition		 Fam13atm2a(KOMP)Wtsi/Fam13atm2a(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Cell Lines EPD0367_2_F12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam13atm2a(KOMP)Wtsi mutation (1 available); any Fam13a mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to injury ( J:263192 )
• unlike wild-type C57BL/6 mice, mice are resistant to cigarette-smoke induced emphysema with normal lung compliance, pressure-volume loops, lung inflammation and alveolar septal cell proliferation
• however, co-administration of PKF118-310 reverses protection from airspace enlargement and co-administration of PPE and PKF118-310 exhibit increased alveolar septal cell proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory