Phenotypes associated with this allele

• Allele Symbol: Tacr2^{tm1(KOMP)Wtsi}
• Allele Name: targeted mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:4420122
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tacr2^tm1(KOMP)Wtsi/Tacr2^tm1(KOMP)Wtsi	involves: C57BL/6N	MGI:6513200

Genotype
MGI:6513200

hm1

• Allelic Composition: Tacr2^{tm1(KOMP)Wtsi}/Tacr2^{tm1(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:302970 )

♂ • basal glucose levels are increased in homozygous male mice on a high fat diet compared to diet matched controls

decreased circulating luteinizing hormone level ( J:302970 )

♀ • significantly attenuated increase in serum luteinizing hormone (LH) levels in response to NK2R agonist treatment in females, but not males, compared to similarly treated wild-type controls

♀ • however, LH responses to other TAC receptor agonists and Kp-10 are similar to controls

♀ • in ovariectomized females with estradiol replacement treatment basal and mean LH levels are reduced

reproductive system

reproductive system phenotype ( J:302970 )

N • timing of puberty and fertility are similar to wild-type controls

behavior/neurological

behavior/neurological phenotype ( J:302970 )

N • social interaction and sexual preference behavior are similar to wild-type controls