Analysis Tools
behavior/neurological
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• at 14 months of age, mutants are impaired in a passive avoidance learning test, with mice not avoiding the corners as much as controls during the acquisition phase or 24 hours later
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• at 14 months of age, mutants require a longer time to habituate the corner visit response when placed inside the IntelliCage environment
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• in the object recognition task, mutants explore the objects more during the sample phase
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• young mutants show less exploratory behavior than controls during the initial adaptation period to the IntelliCage, showing a lower number of corner visits and visits with licks
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• mutants perseverate in place preference extinction test at 4 and 14 months of age
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• mice show lower water consumption under basal conditions at 4 months, but not 14 months, of age
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• when a novel stimulus (smell at 4 months or aversive air-puffs at 4 months and 14 months) is presented in the familiar environment of IntelliCage, mutants do not inhibit their approaches to the corners as controls do, indicating behavioral disinhibition
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• mutants repeat in visiting previously rewarded corners whereas controls are less likely to do so, indicating lower alternation rates and stereotypy
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growth/size/body
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• reduction in body weight, with the difference in average body weight being 14.8% at 4 months and 27% at 10 months
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homeostasis/metabolism
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• mice exhibit extensive plaque pathology at 17 months of age
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nervous system
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• mice exhibit extensive plaque pathology at 17 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:162999 | ||
