Phenotypes associated with this allele

• Allele Symbol: Hes7^tm1.1Dihz
• Allele Name: targeted mutation 1.1, David Ish-Horowicz
• Allele ID: MGI:4420236
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hes7^tm1.1Dihz/Hes7^tm1.1Dihz	Not Specified	MGI:4420258

Genotype
MGI:4420258

hm1

• Allelic Composition: Hes7^tm1.1Dihz/Hes7^tm1.1Dihz
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Differential requirments for hypomorphic Hes7^tm1.1Dihz during segmentation

mortality/aging

decreased survivor rate ( J:155378 )

• only 22% of the expected number of homozygotes survive to weaning

postnatal lethality, incomplete penetrance ( J:155378 )

• only 22% of the expected number of homozygotes survive to weaning

skeleton

decreased rib number ( J:155378 )

• segmentation defects in the cervical, thoracic, and lumbar areas resulting in fewer ribs

vertebral fusion ( J:155378 )

• segmentation defects in the cervical, thoracic, and lumbar areas resulting in fused vertebra

limbs/digits/tail

short tail ( J:155378 )

• truncation of the tail is not as severe as in homozygous null mice