mortality/aging
• survival is improved compared to null mice not carrying the transgene but still less than that of wild-type controls
• relative viability compared to wild-type controls is 20%
|
skeleton
• severely disorganized and truncated axial skeleton with irregular and fused vertebrae and vertebral bodies that rarely align with the midline
|
• rescue of abnormalities is confined to segmentation of the tail area
|
• truncated axial skeleton
|
limbs/digits/tail
kinked tail
(
J:155378
)