Phenotypes associated with this allele

• Allele Symbol: Tg(Lfng*-LFNG)2Dihz
• Allele Name: transgene insertion 2, David Ish-Horowicz
• Allele ID: MGI:4420245
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng*-LFNG)2Dihz/0	involves: 129S7/SvEvBrd * C57BL/6J * CBA	MGI:4420254
tg2	Tg(Lfng*-LFNG)2Dihz/Tg(Lfng*-LFNG)2Dihz	involves: C57BL/6J * CBA	MGI:4420257

Genotype
MGI:4420254

cx1

• Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo; Tg(Lfng*-LFNG)2Dihz/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• relative viability compared to wild-type controls is 9%

skeleton

abnormal axial skeleton morphology ( J:155378 )

• severely disorganized and truncated axial skeleton with irregular and fused vertebrae and vertebral bodies that rarely align with the midline

abnormal vertebral column morphology ( J:155378 )

abnormal thoracic vertebrae morphology ( J:155378 )

• slight restoration of thoracic vertebrae morphology compared to null mice not carrying the transgene

abnormal cervical vertebrae morphology ( J:155378 )

• slight restoration of cervical vertebrae morphology compared to null mice not carrying the transgene

abnormal lumbar vertebrae morphology ( J:155378 )

• slight restoration of lumbar vertebrae morphology compared to null mice not carrying the transgene

short vertebral column ( J:155378 )

• truncated axial skeleton

limbs/digits/tail

short tail ( J:155378 )

• tails are longer than in null mice not carrying the transgene but still shorter than in wild-type controls

Genotype
MGI:4420257

tg2

• Allelic Composition: Tg(Lfng*-LFNG)2Dihz/Tg(Lfng*-LFNG)2Dihz
• Genetic Background: involves: C57BL/6J * CBA

mortality/aging

premature death ( J:155378 )

• stated to be lethal, no time of death provided