Phenotypes associated with this allele

• Allele Symbol: Tg(Lfng-LFNG)1Dihz
• Allele Name: transgene insertion 1, David Ish-Horowicz
• Allele ID: MGI:4420246
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lfng^tm1.1Dihz/Lfng^tm1.1Dihz Tg(Lfng-LFNG)1Dihz/0	involves: 129 * C57BL/6J * CBA	MGI:5426226
cx2	Lfng^tm1Rjo/Lfng^tm1Rjo Tg(Lfng-LFNG)1Dihz/0	involves: 129S7/SvEvBrd * C57BL/6J * CBA	MGI:4420255

Genotype
MGI:5426226

cx1

• Allelic Composition: Lfng^tm1.1Dihz/Lfng^tm1.1Dihz; Tg(Lfng-LFNG)1Dihz/0
• Genetic Background: involves: 129 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:184024 )

N • mice exhibit normal somite length

Genotype
MGI:4420255

cx2

• Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo; Tg(Lfng-LFNG)1Dihz/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Regional and dose-dependent rescue of the Lfng phenotype by transgenic expression in the stripe domain

mortality/aging

decreased survivor rate ( J:155378 )

• survival is improved compared to null mice not carrying the transgene but still less than that of wild-type controls

• relative viability compared to wild-type controls is 33%

skeleton

increased rib number ( J:155378 )

• many mice have extra pair of true ribs

increased thoracic vertebrae number ( J:155378 )

• many mice have extra rib-bearing thoracic vertebrae

decreased lumbar vertebrae number ( J:155378 )

• many mice are missing a lumbar vertebra

vertebral transformation ( J:155378 )

• many mice have extra rib-bearing thoracic vertebra indicating homeotic transformation

reproductive system

male infertility ( J:155378 )

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