Phenotypes associated with this allele

• Allele Symbol: Tg(Nes-cre/Esr1*)1Kuan
• Allele Name: transgene insertion 1, Chia-Yi Kuan
• Allele ID: MGI:4420448
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Itgb1^tm1Mll/Itgb1^tm1Mll Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Tg(Nes-cre/Esr1*)1Kuan/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB	MGI:5467514
tg2	Tg(Nes-cre/Esr1*)1Kuan/Tg(Nes-cre/Esr1*)1Kuan	involves: C57BL/6	MGI:4430291

Genotype
MGI:5467514

cn1

• Allelic Composition: Itgb1^tm1Mll/Itgb1^tm1Mll; Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Tg(Nes-cre/Esr1*)1Kuan/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cerebellum external granule cell layer morphology ( J:191222 )

• tamoxifen-treated mice exhibit increased number of granule cell precursors in the external granule layer

abnormal Bergmann glial cell morphology ( J:191222 )

• tamoxifen-treated mice exhibit disorganized Bergmann glial scaffolds with loose and wavy glial fibers

• endfeet of Bergmann glial fibers in tamoxifen-treated mice fail to maintain adhesion to the basement membrane unlike in control mice

ectopic cerebellar granule cells ( J:191222 )

• granule cells in tamoxifen-treated mice are trapped in the external granule layer unlike in control mice

abnormal cerebellum fissure morphology ( J:191222 )

• at P19, tamoxifen-treated mice exhibit severely compromised ingression of several fissures compared with control mice

abnormal cerebellum lobule morphology ( J:191222 )

• tamoxifen-treated mice exhibit the same lobule defects as in Ric8^tm1Zhua/Ric8^tm1Zhua Tg(GFAP-cre)25Mes mice

• however, fissural basement membrane is normal

abnormal cerebellar foliation ( J:191222 )

• tamoxifen-treated mice exhibit the same lobule defects as in Ric8^tm1Zhua/Ric8^tm1Zhua Tg(GFAP-cre)25Mes mice

Genotype
MGI:4430291

tg2

• Allelic Composition: Tg(Nes-cre/Esr1*)1Kuan/Tg(Nes-cre/Esr1*)1Kuan
• Genetic Background: involves: C57BL/6

normal phenotype

no abnormal phenotype detected ( J:156372 )

• mice are viable and fertile