Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-LRRK2*)D10Cai
• Allele Name: transgene insertion D10, Huaibin Cai
• Allele ID: MGI:4420818
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-LRRK2*)D10Cai/0	involves: C57BL/6	MGI:4420997
cx2	Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-LRRK2*)D10Cai/0 Tg(tetO-SNCA*A53T)E2Cai/0	involves: C57BL/6	MGI:4420998

Genotype
MGI:4420997

cx1

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-LRRK2*)D10Cai/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron morphology ( J:156512 )

• increased framentation of the Golgi complex is observed in KD mice

Genotype
MGI:4420998

cx2

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-LRRK2*)D10Cai/0; Tg(tetO-SNCA*A53T)E2Cai/0
• Genetic Background: involves: C57BL/6

nervous system

abnormal nervous system morphology ( J:156512 )

• increasing accumulation of alpha-synuclein is detected in cell bodies at 1 month in A53T/KD mice compared to KD animals

abnormal neuron morphology ( J:156512 )

• increased framentation of the Golgi complex is observed

abnormal nervous system physiology ( J:156512 )

• neuropathology is accelerated in A53T/KD mice compared to A53T mice