All Phenotypes Gadd45gip1<tm1Kong> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gadd45gip1^tm1Kong/Gadd45gip1^tm1Kong	involves: 129P2/OlaHsd * C57BL/6	MGI:4420971
cn2	Gadd45gip1^tm1Kong/Gadd45gip1^tm2Kong	involves: 129P2/OlaHsd * C57BL/6	MGI:4420972

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:156583 )

• die around E6.5

embryo

increased embryonic tissue cell apoptosis ( J:156583 )

• in embryos at E6.5

• E3.5 embryos cultured for 3 days display many apoptotic cells

absent inner cell mass proliferation ( J:156583 )

• after 3 days in culture, the inner cell mass fails to exhibit outgrowth from the blastocyst

embryonic growth retardation ( J:156583 )

• severely growth retarded at E6.5

decreased embryo size ( J:156583 )

• at E6.5

absent proamniotic cavity ( J:156583 )

• absence of the proamniotic cavity at E6.5

cellular

increased embryonic tissue cell apoptosis ( J:156583 )

• in embryos at E6.5

• E3.5 embryos cultured for 3 days display many apoptotic cells

decreased cell proliferation ( J:156583 )

• in embryos at E6.5

absent inner cell mass proliferation ( J:156583 )

• after 3 days in culture, the inner cell mass fails to exhibit outgrowth from the blastocyst

growth/size/body

embryonic growth retardation ( J:156583 )

• severely growth retarded at E6.5

decreased embryo size ( J:156583 )

• at E6.5

Allelic Composition	Gadd45gip1^tm1Kong/Gadd45gip1^tm2Kong
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45gip1^tm1Kong mutation (0 available); any Gadd45gip1 mutation (19 available)
Gadd45gip1^tm2Kong mutation (0 available); any Gadd45gip1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:156583 )

• following retroviral cre infection, addition of SV40 large T antigen with or without STAT3-C fails to allow MEFs to develop anchorage independent growth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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