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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Creb5tm1Sis
targeted mutation 1, Shunsuke Ishii
MGI:4421136
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Creb5tm1Sis/Creb5tm1Sis involves: C57BL/6 * CBA MGI:4421137
cx2
 		Atf2tm1Sis/Atf2tm1Sis
Creb5tm1Sis/Creb5tm1Sis 		involves: C57BL/6 * CBA MGI:4421138
cx3
 		Atf2tm1Sis/Atf2+
Creb5tm1Sis/Creb5+ 		involves: C57BL/6 * CBA MGI:4421139


Genotype
MGI:4421137
hm1
Allelic
Composition		 Creb5tm1Sis/Creb5tm1Sis
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb5tm1Sis mutation (1 available); any Creb5 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:156376 )
• die immediately after birth




Genotype
MGI:4421138
cx2
Allelic
Composition		 Atf2tm1Sis/Atf2tm1Sis
Creb5tm1Sis/Creb5tm1Sis
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Sis mutation (2 available); any Atf2 mutation (89 available)
Creb5tm1Sis mutation (1 available); any Creb5 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell differentiation ( J:156376 )
• MEFs display reduced adipocyte differentiation compared to double heterozygous cells and wild-type cells
• overexpression of PPARG rescues the defect in adipocyte differentiation in MEFs




Genotype
MGI:4421139
cx3
Allelic
Composition		 Atf2tm1Sis/Atf2+
Creb5tm1Sis/Creb5+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Sis mutation (2 available); any Atf2 mutation (89 available)
Creb5tm1Sis mutation (1 available); any Creb5 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
adipose tissue phenotype ( J:156376 )
N
• unlike in white adipose tissue, no defects are detected in the brown adipose tissue
decreased subcutaneous adipose tissue amount ( J:156376 )
• decrease in the weight of subcutaneous WAT relative to total body weight compared to wild-type controls
decreased white adipose tissue amount ( J:156376 )
• decrease in WAT weight compared to wild-type controls
• decrease in the weight of visceral WAT relative to total body weight compared to wild-type controls

homeostasis/metabolism
improved glucose tolerance ( J:156376 )
• display less high fat diet induced hyperglycemia in an intraperitoneal glucose tolerance test
increased insulin sensitivity ( J:156376 )
• hypoglycemic response to insulin is increased compared to wild-type controls

cellular
abnormal cell differentiation ( J:156376 )
• MEFs display reduced adipocyte differentiation compared to wild-type cells

behavior/neurological
behavior/neurological phenotype ( J:156376 )
N
• despite the decrease in white adipose tissue weight, no difference in cumulative food intake is detected

growth/size/body
growth/size/body region phenotype ( J:156376 )
N
• despite the decrease in white adipose tissue weight, no difference in total body weight is detected

integument
decreased subcutaneous adipose tissue amount ( J:156376 )
• decrease in the weight of subcutaneous WAT relative to total body weight compared to wild-type controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory