Analysis Tools
mortality/aging
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• although present in normal Mendelian ratios at E14.5, fewer than expected live mice are born
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• although present in normal Mendelian ratios at E14.5, fewer than expected live mice are born
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hematopoietic system
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• mice exhibit normal bleeding
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• at 6 to 7 weeks and worsening with age in some mice
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• spleen weight is more than 3 times that weight of normal spleens
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• a 2-fold decrease in Ter119+ cells indicates impaired erythropoiesis
• precursor populations relative to mature cells and cell death are increased in the bone marrow and spleen indicating ineffective erythropoiesis
• fetal liver cells exhibit a delay in cell cycle maturation and maturation compared to in wild-type mice
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• the number of hematopoeitic cells including Ter11+ cells is increased in the spleen compared to in wild-type mice
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• mice exhibit signs of a mild compensated anemia unlike in wild-type mice
• in some mice anemia worsens with age
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• however, endo-reduplication and megakaryocyte numbers are normal
• the cytoplasmic to nuclear ratio is decreased compared to in wild-type cells
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• bone marrow cultured in the presence of thrompoietin for only small colonies unlike similarly treated wild-type cells
• however, in vivo exhibit a normal number of megakaryocytes
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• red blood cell distribution width is increased compared to in wild-type mice
• however, mice exhibit no microcytosis and normal red blood cell count, hemoglobin concentration, and hematocrit
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• 2-fold
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• platelets exhibit an increase in lysosomal-like vacuoles compared with wild-type cells
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• platelets exhibit a paucity of alpha-granules compared with wild-type cells
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• mice exhibit macrothrombocytopenia unlike wild-type mice
(J:156393)
• platelet counts are reduced to 11% of platelet counts in wild-type mice
(J:156393)
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• occasionally
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• 2-fold
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• reticulocyte counts are increased compared to in wild-type mice
• some anemic mice exhibit peripheral reticulocytosis unlike wild-type mice
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• at E12.5
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immune system
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• at 6 to 7 weeks and worsening with age in some mice
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• spleen weight is more than 3 times that weight of normal spleens
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• 2-fold
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• 2-fold
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• at E12.5
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• plasma levels of CXCL4, CXCL5, and CXCL7 are attenuated compared to in wild-type mice
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cardiovascular system
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• modest
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homeostasis/metabolism
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• plasma levels of CXCL4, CXCL5, and CXCL7 are attenuated compared to in wild-type mice
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growth/size/body
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• modest
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• at 6 to 7 weeks and worsening with age in some mice
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• spleen weight is more than 3 times that weight of normal spleens
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