All Phenotypes Lmo4<tm1Gan> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmo4^tm1Gan/Lmo4^tm1Gan	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J	MGI:4421422
cn2	Lmo4^tm1Gan/Lmo4^tm2.1Gan Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J	MGI:4421423

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:156733 )

• mice die at birth

hearing/vestibular/ear

abnormal ear development ( J:156733 )

• at E11.5, the vertical canal outpouch is absent unlike in wild-type mice

• at E11.5, cell proliferation in the otic region is decreased compared to in wild-type mice

• rudiment epithelial invagination at the posterolateral boundary of the inner ear is less than in wild-type mice

• epithelial cells do not push inward within close proximity of the medial layer unlike in wild-type mice

• at E11.5, apoptosis of cells in the developing endolymphatic duct is decreased 10.5-fold compared to in wild-type mice

• at E10.5 and E11.5, apoptosis in the ventromedial region of the otocyst is increased compared to in wild-type mice

• however, initial patterning of the developing otocyst is normal

small otic vesicle ( J:156733 )

• at E10

decreased cochlea coiling ( J:156733 )

• only 1 and one quarter turn compared to 1 and three quarter in wild-type mice

abnormal semicircular canal ampulla morphology ( J:156733 )

• at E15.5, mice lack anterior and posterior ampullae unlike in wild-type mice

• however, the lateral ampullae is present

absent semicircular canals ( J:156733 )

abnormal endolymphatic duct morphology ( J:156733 )

• slightly larger than in wild-type mice at E15.5

nervous system

abnormal neural tube closure ( J:156733 )

• in 30% of mice

exencephaly ( J:156733 )

• in 30% of mice

craniofacial

acrania ( J:156733 )

• in 30% of mice

embryo

abnormal neural tube closure ( J:156733 )

• in 30% of mice

skeleton

acrania ( J:156733 )

• in 30% of mice

Allelic Composition	Lmo4^tm1Gan/Lmo4^tm2.1Gan Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Lmo4^tm1Gan mutation (0 available); any Lmo4 mutation (9 available)
Lmo4^tm2.1Gan mutation (0 available); any Lmo4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal inner ear morphology ( J:156733 )

• at E15.5, mice exhibit vestibular defects observed in Lmo4^tm1Gan homozygotes

abnormal semicircular canal ampulla morphology ( J:156733 )

• at E15.5, mice lack anterior and posterior ampullae unlike in wild-type mice

absent semicircular canals ( J:156733 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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