All Phenotypes Lmo4<tm2.1Gan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lmo4^tm2.1Gan
targeted mutation 2.1, Lin Gan
MGI:4421414

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lmo4^tm1Gan/Lmo4^tm2.1Gan Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J	MGI:4421423
cn2	Lmo4^tm2.1Gan/Lmo4^tm2.1Gan Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:4421425

Allelic Composition	Lmo4^tm1Gan/Lmo4^tm2.1Gan Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Lmo4^tm1Gan mutation (0 available); any Lmo4 mutation (9 available)
Lmo4^tm2.1Gan mutation (0 available); any Lmo4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal inner ear morphology ( J:156733 )

• at E15.5, mice exhibit vestibular defects observed in Lmo4^tm1Gan homozygotes

abnormal semicircular canal ampulla morphology ( J:156733 )

• at E15.5, mice lack anterior and posterior ampullae unlike in wild-type mice

absent semicircular canals ( J:156733 )

Allelic Composition	Lmo4^tm2.1Gan/Lmo4^tm2.1Gan Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J