Phenotypes associated with this allele

• Allele Symbol: Zfpm1^tm1.1Esv
• Allele Name: targeted mutation 1.1, Eric C Svensson
• Allele ID: MGI:4421436
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfpm1^tm1.1Esv/Zfpm1^tm1.1Esv	involves: 129S6/SvEvTac * C57BL/6	MGI:4421437

Genotype
MGI:4421437

hm1

• Allelic Composition: Zfpm1^tm1.1Esv/Zfpm1^tm1.1Esv
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:156475 )

• partial embryonic lethality as early as 10.5

embryo

pale yolk sac ( J:156475 )

• in the portion of homozygous mice that die during organogenesis

cardiovascular system

pericardial edema ( J:156475 )

• in the portion of homozygous mice that die during organogenesis

homeostasis/metabolism

pericardial edema ( J:156475 )

• in the portion of homozygous mice that die during organogenesis

hematopoietic system

abnormal megakaryocyte differentiation ( J:156475 )

• megakaryocytes show a reduced polyploidization

• expression analysis shows inappropriate expression of mast cell and eosinophil specific genes in the megakaryocyte lineages

abnormal common myeloid progenitor cell morphology ( J:156475 )

• an increased number of myeloid colonies is observed in IL3 treated bone marrow and spleen in an in vitro myeloid colony-formation assay.

• significant decrease in the fraction of CD41-positive cells in the bone marrow of mutant mice

abnormal erythropoiesis ( J:156475 )

• in bone marrow a 1.8-fold decrease is seen in the proportion of Ter119hi CD71lo cells, which represent the most mature orthochromatic population

• expression analysis shows inappropriate expression of mast cell and eosinophil specific genes in the erythroid lineage

extramedullary hematopoiesis ( J:156475 )

• number of erythroid colony-forming units increased more than 20-fold in spleens by flow cytometry

• a four-fold increase in the proportion of Ter119hi CD71hi basophilic erythroid progenitors in the spleen

abnormal bone marrow cell number ( J:156475 )

• a 1.8-fold decrease in the proportion of Ter119hi CD71lo cells, which represent the most mature orthochromatic population

• increase in the number of granulocytes in the bone marrow

decreased megakaryocyte cell number ( J:156475 )

increased erythroid progenitor cell number ( J:156475 )

• number of erythroid colony-forming units increased more than 20-fold in spleens by flow cytometry

• a four-fold increase in the proportion of Ter119hi CD71hi basophilic erythroid progenitors in the spleen

abnormal megakaryocyte progenitor cell morphology ( J:156475 )

• a 5.4-fold increase in the number of colony-forming units present in an in vitro colony forming assay from spleen

• the colonies derived from bone marrow cells are much smaller and contain significantly fewer acetylcholinesterase positive cells

increased erythrocyte cell number ( J:156475 )

• a preponderance of erythrocytes within the red pulp

increased hemoglobin concentration distribution width ( J:156475 )

• 6-8 week old mice display increased red cell distribution width

increased granulocyte number ( J:156475 )

• 6-8 week old mice display granulocytosis in peripheral blood

• in bone marrow histologically and by flow cytometry

increased neutrophil cell number ( J:156475 )

• peripheral neutrophil counts are elevated 3.1-fold

thrombocytopenia ( J:156475 )

• at 6-8 weeks of age

increased mean platelet volume ( J:156475 )

• at 6-8 weeks of age

abnormal spleen morphology ( J:156475 )

• number of erythroid colony-forming units increased more than 20-fold in spleens by flow cytometry

• a four-fold increase in the proportion of Ter119hi CD71hi basophilic erythroid progenitors in the spleen

increased spleen weight ( J:156475 )

• spleen weight to body weight ratios are increased by 200%

increased spleen red pulp amount ( J:156475 )

• prominent expansion with a preponderance of erythrocytes within the red pulp

immune system

increased granulocyte number ( J:156475 )

• 6-8 week old mice display granulocytosis in peripheral blood

• in bone marrow histologically and by flow cytometry

increased neutrophil cell number ( J:156475 )

• peripheral neutrophil counts are elevated 3.1-fold

abnormal spleen morphology ( J:156475 )

• number of erythroid colony-forming units increased more than 20-fold in spleens by flow cytometry

• a four-fold increase in the proportion of Ter119hi CD71hi basophilic erythroid progenitors in the spleen

increased spleen weight ( J:156475 )

• spleen weight to body weight ratios are increased by 200%

increased spleen red pulp amount ( J:156475 )

• prominent expansion with a preponderance of erythrocytes within the red pulp

cellular

abnormal megakaryocyte differentiation ( J:156475 )

• megakaryocytes show a reduced polyploidization

• expression analysis shows inappropriate expression of mast cell and eosinophil specific genes in the megakaryocyte lineages

growth/size/body

increased spleen weight ( J:156475 )

• spleen weight to body weight ratios are increased by 200%