Phenotypes associated with this allele

• Allele Symbol: Cebpb^tm1.1Maka
• Allele Name: targeted mutation 1.1, Masato Kasuga
• Allele ID: MGI:4421439
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Ins2^Akita/Ins2^Akita Tg(Ins2-cre)23Herr/0	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J	MGI:4421497
cn2	Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Lepr^db/Lepr^db Tg(Ins2-cre)23Herr/0	involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J	MGI:4421499
cn3	Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:4421496

Genotype
MGI:4421497

cn1

• Allelic Composition: Cebpb^tm1.1Maka/Cebpb^tm1.1Maka; Ins2^Akita/Ins2^Akita; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal glucose and insulin homeostasis in Ins2^Akita/Ins2^Akita and Ins2^Akita/Ins2^Akita Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 but not Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 mice.

endocrine/exocrine glands

abnormal pancreatic islet cell apoptosis ( J:156725 )

• expression of apoptosis markers in the pancreas islet is decreased compared to in Ins2^Akita homozygotes

abnormal pancreatic beta cell mass ( J:156725 )

• mice exhibit improved beta cell mass compared to in Ins2^Akita homozygotes

decreased insulin secretion ( J:156725 )

• pancreatic insulin levels are decreased compared to in wild-type mice

• however, pancreatic insulin content is 8-fold higher than in Ins2^Akita homozygotes

homeostasis/metabolism

decreased insulin secretion ( J:156725 )

• pancreatic insulin levels are decreased compared to in wild-type mice

• however, pancreatic insulin content is 8-fold higher than in Ins2^Akita homozygotes

increased circulating glucose level ( J:156725 )

• mice exhibit increased circulating glucose levels compared to in wild-type mice

• however, glucose serum level are increased compared to in Ins2^Akita homozygotes

decreased circulating insulin level ( J:156725 )

• mice exhibit decreased circulating glucose levels compared to in wild-type mice

• however, insulin serum level are increased compared to in Ins2^Akita homozygotes

cellular

abnormal pancreatic islet cell apoptosis ( J:156725 )

• expression of apoptosis markers in the pancreas islet is decreased compared to in Ins2^Akita homozygotes

Genotype
MGI:4421499

cn2

• Allelic Composition: Cebpb^tm1.1Maka/Cebpb^tm1.1Maka; Lepr^db/Lepr^db; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

Increased beta cell mass in Lepr^db/Lepr^db mice and Lepr^db/Lepr^db Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 mice

endocrine/exocrine glands

abnormal pancreatic islet cell apoptosis ( J:156725 )

• pancreatic islet cell apoptosis is decreased compared to in Lepr^db homozygotes

increased pancreatic beta cell mass ( J:156725 )

• compared to in Lepr^db homozygotes

homeostasis/metabolism

hyperglycemia ( J:156725 )

• hyperglycemia develops more slowly and is ameliorated compared to in Lepr^db homozygotes

increased circulating insulin level ( J:156725 )

• at 12 weeks, plasma insulin levels are increased compared to in Lepr^db homozygotes and wild-type mice

cellular

abnormal pancreatic islet cell apoptosis ( J:156725 )

• pancreatic islet cell apoptosis is decreased compared to in Lepr^db homozygotes

Genotype
MGI:4421496

cn3

• Allelic Composition: Cebpb^tm1.1Maka/Cebpb^tm1.1Maka; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Higher plasma insulin levels and increased pancreatic insulin content in Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 mice

endocrine/exocrine glands

increased insulin secretion ( J:156725 )

• pancreas insulin levels are higher than in Cebpb^tm1.1Maka homozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:156725 )

N • mice exhibit normal circulating insulin and glucose levels

increased insulin secretion ( J:156725 )

• pancreas insulin levels are higher than in Cebpb^tm1.1Maka homozygotes