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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Abl1tm1Goff
targeted mutation 1, Stephen P Goff
MGI:4421531
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Abl1tm1Goff/Abl1tm1Goff involves: C57BL/6 MGI:4421538
cn2
 		Abl1tm1Goff/Abl1tm1Goff
Tg(Myh6-cre)2182Mds/0 		involves: C57BL/6 MGI:4421539


Genotype
MGI:4421538
hm1
Allelic
Composition		 Abl1tm1Goff/Abl1tm1Goff
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1Goff mutation (1 available); any Abl1 mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:156743 )
• high levels of perinatal lethality
• mice are stated to be phenotypically indistinguishable from Abl1 null mice

cardiovascular system
abnormal heart ventricle morphology ( J:156743 )
• decrease in the size of the ventricular lumens

growth/size/body
enlarged heart ( J:156743 )
heart hyperplasia ( J:156743 )




Genotype
MGI:4421539
cn2
Allelic
Composition		 Abl1tm1Goff/Abl1tm1Goff
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1Goff mutation (1 available); any Abl1 mutation (93 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:156743 )
• most die shortly after birth

cardiovascular system
cardiovascular system phenotype ( J:156743 )
N
• compared to homozygous mutant mice not carrying the cre transgene, cardiomyocyte overproliferation and ventricular lumen size reduction are dramatically reduced
thick ventricular wall ( J:156743 )
• not as thick as in homozygous mutant mice not carrying the cre transgene but slightly thicker than in heterozygous controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory