Analysis Tools
immune system
| N |
• mice do not exhibit lymphocyte infiltration of organs and the number and function of T regulatory cells are normal
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• peripheral T cells exhibit increased apoptosis compared to in wild-type mice
• apoptosis cannot be prevented by adding the blocking anti-FasL antibodies unlike in wild-type cultures
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• progressively as mice age
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• progressively as mice age
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• nearly all T cells exhibit an activated phenotype in the absence of an overt antigen challenge unlike in wild-type mice
• following stimulation with anti-CD3 plus anti-CD28 antibodies or phorbol 12-myristate 13-acetate plus ionomycin, a higher percentage of CD4+ T cells produce IL-1 and CD8+ cells produce IL-2 and IFN-gamma compared to in treated wild-type mice
• T cells acquire the activated phenotype during the double positive to single positive thymocyte transition by a cell-autonomous mechanism
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hematopoietic system
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• peripheral T cells exhibit increased apoptosis compared to in wild-type mice
• apoptosis cannot be prevented by adding the blocking anti-FasL antibodies unlike in wild-type cultures
|
|
• progressively as mice age
|
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• progressively as mice age
|
|
• nearly all T cells exhibit an activated phenotype in the absence of an overt antigen challenge unlike in wild-type mice
• following stimulation with anti-CD3 plus anti-CD28 antibodies or phorbol 12-myristate 13-acetate plus ionomycin, a higher percentage of CD4+ T cells produce IL-1 and CD8+ cells produce IL-2 and IFN-gamma compared to in treated wild-type mice
• T cells acquire the activated phenotype during the double positive to single positive thymocyte transition by a cell-autonomous mechanism
|
cellular
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• peripheral T cells exhibit increased apoptosis compared to in wild-type mice
• apoptosis cannot be prevented by adding the blocking anti-FasL antibodies unlike in wild-type cultures
|
