Phenotypes associated with this allele

• Allele Symbol: Agr2^tm1.1Lpkn
• Allele Name: targeted mutation 1.1, Steven M Lipkin
• Allele ID: MGI:4421687
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Agr2^tm1.1Lpkn/Agr2^tm1.1Lpkn Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+	involves: 129 * 129S6/SvEvTac * C57BL/6	MGI:4421701

Genotype
MGI:4421701

cn1

• Allelic Composition: Agr2^tm1.1Lpkn/Agr2^tm1.1Lpkn; Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:156704 )

• tamoxifen-treated mice lack normal goblet cells unlike wild-type mice

• 3 days following tamoxifen treatment, mice show loss of normal goblet cells, acute inflammatory infiltrates in the lamina propria, and further expansion of the Paneth cells compared to in wild-type mice

increased enterocyte apoptosis ( J:156704 )

• in the small intestine and colon following tamoxifen treatment

abnormal enterocyte proliferation ( J:156704 )

• following tamoxifen treatment, enterocyte proliferation in the small intestine and colon is decreased compared to in wild-type mice

abnormal enterocyte morphology ( J:156704 )

• 3 days following tamoxifen treatment, mice show loss of normal goblet cells, acute inflammatory infiltrates in the lamina propria, and further expansion of the Paneth cells unlike in wild-type mice

increased Paneth cell number ( J:156704 )

• 24 hours following tamoxifen treatment, the Paneth cell compartment is expanded compared to in wild-type mice

• 3 days following tamoxifen treatment, mice show loss of normal goblet cells, acute inflammatory infiltrates in the lamina propria, and further expansion of the Paneth cells compared to in wild-type mice

colitis ( J:156704 )

• 3 days following tamoxifen treatment, mice show loss of normal goblet cells, acute inflammatory infiltrates in the lamina propria, and further expansion of the Paneth cells compared to in wild-type mice

immune system

colitis ( J:156704 )

• 3 days following tamoxifen treatment, mice show loss of normal goblet cells, acute inflammatory infiltrates in the lamina propria, and further expansion of the Paneth cells compared to in wild-type mice

endocrine/exocrine glands

increased Paneth cell number ( J:156704 )

• 24 hours following tamoxifen treatment, the Paneth cell compartment is expanded compared to in wild-type mice

• 3 days following tamoxifen treatment, mice show loss of normal goblet cells, acute inflammatory infiltrates in the lamina propria, and further expansion of the Paneth cells compared to in wild-type mice

cellular

abnormal intestinal goblet cell morphology ( J:156704 )

• tamoxifen-treated mice lack normal goblet cells unlike wild-type mice

• 3 days following tamoxifen treatment, mice show loss of normal goblet cells, acute inflammatory infiltrates in the lamina propria, and further expansion of the Paneth cells compared to in wild-type mice

increased enterocyte apoptosis ( J:156704 )

• in the small intestine and colon following tamoxifen treatment

abnormal enterocyte proliferation ( J:156704 )

• following tamoxifen treatment, enterocyte proliferation in the small intestine and colon is decreased compared to in wild-type mice