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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd74tm1Anjm
targeted mutation 1, Andrew N J McKenzie
MGI:4421688
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Smim3tm1Anjm/Smim3+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4421776
cn2
 		Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4421779
cn3
 		Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53tm1Brd 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4421780
cn4
 		Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:4421775
cx5
 		Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:4421699


Genotype
MGI:4421776
cn1
Allelic
Composition		 Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Smim3tm1Anjm/Smim3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (36 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased granulocyte monocyte progenitor cell number ( J:155870 )
• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow
• by flow cytometry, there is a reduced number of granulocyte-monocyte progenitors in the bone marrow
decreased erythroid progenitor cell number ( J:155870 )
• a decrease in erythroid colony-forming units in the bone marrow
decreased erythrocyte cell number ( J:155870 )
• there are a reduced numbers of circulating red blood cells
decreased hematopoietic stem cell number ( J:155870 )
• in bone marrow and spleen
decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )
• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors in the bone marrow

skeleton
abnormal bone marrow morphology ( J:155870 )
• bone marrow dysplasia

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chromosome 5q deletion syndrome DOID:0090016 OMIM:153550
 J:155870




Genotype
MGI:4421779
cn2
Allelic
Composition		 Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (36 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (9 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased granulocyte monocyte progenitor cell number ( J:155870 )
• a decrease in granulocyte/macrophage colony-forming units in bone marrow
• by flow cytometry, there is a reduction in granulocyte-monocyte progenitors in the bone marrow
decreased erythroid progenitor cell number ( J:155870 )
• as measured by erythroid colony-forming units in bone marrow
decreased erythrocyte cell number ( J:155870 )
• a reduced number of circulating red blood cells
decreased hematopoietic stem cell number ( J:155870 )
• in bone marrow and spleen
decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )
• by flow cytometry, there is a reduction in megakaryocytic-erythroid progenitors in the bone marrow




Genotype
MGI:4421780
cn3
Allelic
Composition		 Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (36 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (9 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:155870 )
N
• absence of Trp53 expression completely rescues hematopoetic defects seen in mutant mice wild-type for Trp53

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chromosome 5q deletion syndrome DOID:0090016 OMIM:153550
 J:155870




Genotype
MGI:4421775
cn4
Allelic
Composition		 Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Lmo2tm2(cre)Thr/Lmo2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (36 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell number ( J:155870 )
• an elevated proportion of mast cells in the bone marrow
decreased bone marrow cell number ( J:155870 )
• a reduced number of cells are flushed from the femurs
• histological bone marrow sections have mild to high hypocellularity
decreased granulocyte monocyte progenitor cell number ( J:155870 )
• decreased granulocyte/macrophage colony-forming units
• by flow cytometry, a reduction in granulocyte-monocyte progenitors in the bone marrow
abnormal megakaryocyte morphology ( J:155870 )
• monolobulated megakaryocytes in the bone marrow
decreased erythroid progenitor cell number ( J:155870 )
• a decreased number of erythroid colony-forming units
abnormal megakaryocyte progenitor cell morphology ( J:155870 )
• a decreased number of megakaryocyte colony-forming units
• considerably fewer in the bone marrow by flow cytometry
abnormal blood cell morphology ( J:155870 )
• pencil shaped cells are present in blood smears
abnormal common myeloid progenitor cell morphology ( J:155870 )
• striking decrease in the common myeloid progenitor - megakaryocytic-erythroid progenitor lineage
abnormal erythropoiesis ( J:155870 )
• prominent erythroid dysplasia, dyserythropoiesis
increased red blood cell distribution width ( J:155870 )
• increase in the mean red blood cell distribution width
macrocytosis ( J:155870 )
• in bone marrow and peripheral blood
decreased granulocyte number ( J:155870 )
• total granulocyte numbers are lower in the blood
abnormal mast cell morphology ( J:155870 )
• an elevated proportion of mast cells in the bone marrow
thrombocytopenia ( J:155870 )
• modest
decreased hematopoietic stem cell number ( J:155870 )
• in bone marrow and spleen
decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )
• by flow cytometry, a reduction in megakaryocytic-erythroid progenitors in the bone marrow

immune system
decreased granulocyte number ( J:155870 )
• total granulocyte numbers are lower in the blood
abnormal mast cell morphology ( J:155870 )
• an elevated proportion of mast cells in the bone marrow

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chromosome 5q deletion syndrome DOID:0090016 OMIM:153550
 J:155870




Genotype
MGI:4421699
cx5
Allelic
Composition		 Smim3tm1Anjm/Smim3+
Cd74tm1Anjm/Cd74+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Anjm mutation (0 available); any Cd74 mutation (36 available)
Smim3tm1Anjm mutation (0 available); any Smim3 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:155870 )
N
• no abnormal phenotype associated with the development of red blood cells (RBCs) or platelets




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11/12/2024
MGI 6.24 		The Jackson Laboratory