Phenotypes associated with this allele

• Allele Symbol: Cd300lf^tm1Gne
• Allele Name: targeted mutation 1, Genentech
• Allele ID: MGI:4421781
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd300lf^tm1Gne/Cd300lf^tm1Gne	involves: C57BL/6N	MGI:4421783

Genotype
MGI:4421783

hm1

• Allelic Composition: Cd300lf^tm1Gne/Cd300lf^tm1Gne
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:156819 )

N • T cell responses in the periphery and spinal cord are normal

increased interleukin-1 alpha secretion ( J:156819 )

• leukocytes from in MOG35-55-treated mice

increased interleukin-1 beta secretion ( J:156819 )

• leukocytes from in MOG35-55-treated mice

increased interleukin-12 secretion ( J:156819 )

• leukocytes from in MOG35-55-treated mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:156819 )

• MOG35-55-treated mice exhibit increased disease severity with increased demyelination compared with similarly treated wild-type mice

• leukocytes from MOG35-55-treated mice exhibit increased nitric oxide levels and myeloid-specific pro-inflammatory cytokines (IL1a, IL1b, and IL12) compared with cells from similarly treated wild-type mice

• however, the incidence of disease is normal and reconstituting mice with wild-type bone marrow restores wild-type response to MOG35-55 treatment

nervous system

demyelination ( J:156819 )

• in MOG35-55-treated mice

homeostasis/metabolism

abnormal nitric oxide homeostasis ( J:156819 )

• leukocytes from MOG35-55-treated mice exhibit increased nitric oxide levels and myeloid-specific pro-inflammatory cytokines compared with cells from similarly treated wild-type mice