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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccnd1tm4Pisc
targeted mutation 4, Piotr Sicinski
MGI:4421801
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccnd1tm4Pisc/Ccnd1tm4Pisc involves: 129S4/SvJae * C57BL/6 MGI:4421803
ht2
 		Ccnd1tm3Pisc/Ccnd1tm4Pisc involves: 129S4/SvJae * C57BL/6 MGI:4421804
cx3
 		Ccnd1tm4Pisc/Ccnd1tm4Pisc
Tg(MMTV-Erbb2)NK1Mul/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:4421802


Genotype
MGI:4421803
hm1
Allelic
Composition		 Ccnd1tm4Pisc/Ccnd1tm4Pisc
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm4Pisc mutation (0 available); any Ccnd1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:156591 )
• no defects in neurological development, mammary development, retinal morphology or body size are detected




Genotype
MGI:4421804
ht2
Allelic
Composition		 Ccnd1tm3Pisc/Ccnd1tm4Pisc
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm3Pisc mutation (0 available); any Ccnd1 mutation (22 available)
Ccnd1tm4Pisc mutation (0 available); any Ccnd1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:156591 )
• no defects in neurological development, mammary development, retinal morphology or body size are detected




Genotype
MGI:4421802
cx3
Allelic
Composition		 Ccnd1tm4Pisc/Ccnd1tm4Pisc
Tg(MMTV-Erbb2)NK1Mul/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm4Pisc mutation (0 available); any Ccnd1 mutation (22 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156591 )
• 50% of mice develop tumors by about 45 weeks, same rate of occurrence as transgene alone

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156591 )
• 50% of mice develop tumors by about 45 weeks, same rate of occurrence as transgene alone

integument
increased mammary adenocarcinoma incidence ( J:156591 )
• 50% of mice develop tumors by about 45 weeks, same rate of occurrence as transgene alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory