Phenotypes associated with this allele

• Allele Symbol: Phlpp1^tm1.1Saco
• Allele Name: targeted mutation 1.1, Paolo Sassone-Corsi
• Allele ID: MGI:4421807
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phlpp1^tm1.1Saco/Phlpp1^tm1.1Saco	involves: 129 * 129S4/SvJae	MGI:4421809
hm2	Phlpp1^tm1.1Saco/Phlpp1^tm1.1Saco	involves: 129 * C57BL/6	MGI:5795609
cx3	Phlpp1^tm1.1Saco/Phlpp1^tm1.1Saco Phlpp2^tm1d(EUCOMM)Hmgu/Phlpp2^tm1d(EUCOMM)Hmgu	involves: 129 * C57BL/6N	MGI:5795607

Genotype
MGI:4421809

hm1

• Allelic Composition: Phlpp1^tm1.1Saco/Phlpp1^tm1.1Saco
• Genetic Background: involves: 129 * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:156530 )

N • circadian rhythmicity under constant conditions is normal

abnormal circadian behavior phase ( J:156530 )

• loss of acute tau extension and shortening following phase delaying and phase advancing light shifts

delayed circadian behavior phase ( J:156530 )

• spontaneous shortening of the circadian period several cycles after a 30 min. light pulse during the early subjective night in mice under constant dark conditions

• spontaneous shortening of the circadian period is also seen several days after mice are exposed to 8 h of light

• tau length is shorter after short light exposure than after long light exposure

Genotype
MGI:5795609

hm2

• Allelic Composition: Phlpp1^tm1.1Saco/Phlpp1^tm1.1Saco
• Genetic Background: involves: 129 * C57BL/6

digestive/alimentary system

digestive/alimentary phenotype ( J:231241 )

N • mice exhibit normal susceptibility to DSS-induced colitis

immune system

immune system phenotype ( J:231241 )

N • mice exhibit normal susceptibility to DSS-induced colitis

Genotype
MGI:5795607

cx3

• Allelic Composition: Phlpp1^tm1.1Saco/Phlpp1^tm1.1Saco; Phlpp2^{tm1d(EUCOMM)Hmgu}/Phlpp2^{tm1d(EUCOMM)Hmgu}
• Genetic Background: involves: 129 * C57BL/6N
• Cell Lines: HEPD0619_1_C08

digestive/alimentary system

decreased susceptibility to induced colitis ( J:231241 )

• DSS-treated mice exhibit reduced weight loss, colonic epithelial damage or crypt damage, macrophage infiltration, epithelial cell apoptosis and reduction in colon length compared with wild-type mice

growth/size/body

decreased susceptibility to weight loss ( J:231241 )

• in DSS-treated mice

immune system

decreased susceptibility to induced colitis ( J:231241 )

• DSS-treated mice exhibit reduced weight loss, colonic epithelial damage or crypt damage, macrophage infiltration, epithelial cell apoptosis and reduction in colon length compared with wild-type mice