All Phenotypes Gt(ROSA)26Sor<tm1(Vegfa*)Jhai> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(Vegfa*)Jhai}/Gt(ROSA)26Sor⁺ Tg(Col2a1-cre)1Bhr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL	MGI:4429123
cn2	Gt(ROSA)26Sor^{tm1(Vegfa*)Jhai}/Gt(ROSA)26Sor⁺ Kdr^tm1Wag/Kdr^tm1Wag Tg(Col2a1-cre)1Bhr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL	MGI:4429126
cn3	Gt(ROSA)26Sor^{tm1(Vegfa*)Jhai}/Gt(ROSA)26Sor⁺ Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR	MGI:4429124

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:156474 )

• mice die at birth

skeleton

abnormal long bone morphology ( J:156474 )

• long bones are abnormal and bent (kyphosis) compared to in wild-type mice

• however, skeletal patterning and growth is normal

abnormal long bone diaphysis morphology ( J:156474 )

• at E16.5, limb diaphyses are short and thick compared to in wild-type mice

• at E16.5, primary ossification centers are malformed compared to in wild-type mice

• at E16.5, ossification centers are laterally expanded with excessive, disorganized bone compared to in wild-type mice

decreased width of hypertrophic chondrocyte zone ( J:156474 )

• mild

abnormal rib morphology ( J:156474 )

• at E16.5, rib diaphyses are short and thick compared to in wild-type mice

abnormal bone structure ( J:156474 )

• at E16.5, limb and rib diaphyses are short and thick compared to in wild-type mice

• bone lack a proper cortex and abnormally oriented trabecular-like structures extend inside the bone, obliterating the developing marrow cavity unlike in wild-type mice

• mice exhibit increased blood vessels in the bone compared with wild-type mice

abnormal bone marrow cavity morphology ( J:156474 )

• abnormally oriented trabecular-like structures extend inside the bone, obliterating the developing marrow cavity unlike in wild-type mice

abnormal bone ossification ( J:156474 )

• at E16.5, primary ossification centers are malformed compared to in wild-type mice

• at E16.5, ossification centers are laterally expanded with excessive, disorganized bone compared to in wild-type mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(Vegfa*)Jhai}/Gt(ROSA)26Sor⁺ Kdr^tm1Wag/Kdr^tm1Wag Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Vegfa*)Jhai} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Kdr^tm1Wag mutation (0 available); any Kdr mutation (74 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:156474 )

N	• mice do not exhibit severe long bone kyphosis unlike in Gt(ROSA)26Sor^tm1Jhai Tg(Col2a1-cre)1Bhr mice

abnormal long bone diaphysis morphology ( J:156474 )

• bone shafts in mice are wider than in wild-type mice

abnormal bone structure ( J:156474 )

• mice exhibit hypervascularization in the expanded perichondrial/periosteal region and inside the bone shaft compared with wild-type mice

increased bone mass ( J:156474 )

• mice exhibit an increase in mineralized bone formed compared with wild-type mice that is not as severe as in Gt(ROSA)26Sor^tm1Jhai Tg(Col2a1-cre)1Bhr mice

abnormal skeleton development ( J:156474 )

• mesenchymal hyperproliferation in mice is reduced compared to in Gt(ROSA)26Sor^tm1Jhai Tg(Col2a1-cre)1Bhr mice

cardiovascular system

abnormal blood vessel morphology ( J:156474 )

• mice exhibit hypervascularization in the expanded perichondrial/periosteal region and inside the bone shaft compared with wild-type mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(Vegfa*)Jhai}/Gt(ROSA)26Sor⁺ Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Vegfa*)Jhai} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:156474 )

• bones are abnormally ossified and hypervascularized compared to in wild-type mice

abnormal bone ossification ( J:156474 )

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