Phenotypes associated with this allele

• Allele Symbol: Myd88^m3Btlr
• Allele Name: mutation 3, Bruce Beutler
• Allele ID: MGI:4422086
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myd88^m3Btlr/Myd88^m3Btlr	C57BL/6J-Myd88^m3Btlr	MGI:4422087

Genotype
MGI:4422087

hm1

• Allelic Composition: Myd88^m3Btlr/Myd88^m3Btlr
• Genetic Background: C57BL/6J-Myd88^m3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:156848 )

N • peritoneal macrophages from mice homozygous for this mutation are resistant to infection by mouse cytomegalovirus (MCMV); influenza; Rift Valley Fever virus (RVFV); and an adenoviral vector

N • stimulation by a ligand of every known toll-like receptor (TLR) induces normal tumor necrosis factor (TNF)-alpha production by homozygous mutant macrophages

N • double stranded (ds) DNA induces normal production of type 1 interferon by homozygous mutant macrophages

N • LPS/nigericin induces normal production of interleukin (IL)-1beta by homozygous mutant macrophages