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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdrtm1Wag
targeted mutation 1, Erwin F Wagner
MGI:4422101
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:5471122
cn2
 		Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5471121
cn3
 		Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+
Kdrtm1Wag/Kdrtm1Wag
Tg(Col2a1-cre)1Bhr/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL MGI:4429126
cn4
 		Kdrtm1Wag/Kdrtm1Wag
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4422209


Genotype
MGI:5471122
cn1
Allelic
Composition		 Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (992 available)
Kdrtm1Wag mutation (0 available); any Kdr mutation (74 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal coronary artery morphology ( J:193198 )
• embryos do not develop intramyocardial coronary arteries
abnormal angiogenesis ( J:193198 )
• at E11.5, endocardial cells cannot respond to Vegf120 and fail to migrate, sprout, and form endothelial networks




Genotype
MGI:5471121
cn2
Allelic
Composition		 Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Wag mutation (0 available); any Kdr mutation (74 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:193198 )
• all die prior to birth (after or during E14.5-16.5)

growth/size/body
decreased body size ( J:193198 )
• observed after E14.5 through 16.5

cardiovascular system
abnormal coronary artery morphology ( J:193198 )
• E14.5 embryos have severely diminished or absent coronary arteries, but coronary veins develop
abnormal angiogenesis ( J:193198 )
• a 24% reduction of subepicardial endothelial cell population (for vein formation) is detected at E14.5, with a 74% decrease in intramyocardial endothelial cells (for artery formation) detected
• E12.5 mutants do not develop coronary plexuses in the peritruncal/coronary sulcus area or ventricular septum
abnormal interventricular septum morphology ( J:193198 )
• E12.5 mutants do not develop coronary plexuses in the ventricular septum
heart hemorrhage ( J:193198 )
• embryos develop cardiac hemorrhages at E14.5-16.5




Genotype
MGI:4429126
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+
Kdrtm1Wag/Kdrtm1Wag
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Vegfa*)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Kdrtm1Wag mutation (0 available); any Kdr mutation (74 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:156474 )
N
• mice do not exhibit severe long bone kyphosis unlike in Gt(ROSA)26Sortm1Jhai Tg(Col2a1-cre)1Bhr mice
abnormal long bone diaphysis morphology ( J:156474 )
• bone shafts in mice are wider than in wild-type mice
abnormal bone structure ( J:156474 )
• mice exhibit hypervascularization in the expanded perichondrial/periosteal region and inside the bone shaft compared with wild-type mice
increased bone mass ( J:156474 )
• mice exhibit an increase in mineralized bone formed compared with wild-type mice that is not as severe as in Gt(ROSA)26Sortm1Jhai Tg(Col2a1-cre)1Bhr mice
abnormal skeleton development ( J:156474 )
• mesenchymal hyperproliferation in mice is reduced compared to in Gt(ROSA)26Sortm1Jhai Tg(Col2a1-cre)1Bhr mice

cardiovascular system
abnormal blood vessel morphology ( J:156474 )
• mice exhibit hypervascularization in the expanded perichondrial/periosteal region and inside the bone shaft compared with wild-type mice




Genotype
MGI:4422209
cn4
Allelic
Composition		 Kdrtm1Wag/Kdrtm1Wag
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Wag mutation (0 available); any Kdr mutation (74 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:86207 )
N
• at E13.5, mice exhibit normal developing CNS

behavior/neurological
behavior/neurological phenotype ( J:86207 )
N
• at 1 month, mice exhibit normal behavioral phenotypes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory