Phenotypes associated with this allele

• Allele Symbol: Ewsr1^{tm2(FLI1*)Sblee}
• Allele Name: targeted mutation 2, Sean Lee
• Allele ID: MGI:4429147
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ewsr1^tm2(FLI1*)Sblee/Ewsr1^+ Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4429149

Genotype
MGI:4429149

cn1

• Allelic Composition: Ewsr1^{tm2(FLI1*)Sblee}/Ewsr1⁺; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:156860 )

• after tamoxifen injection, within 4 to 6 days mice become moribund and die

cellular

increased fibroblast apoptosis ( J:156860 )

• 24 hours after tamoxifen application MEF cultures begin to die and caspase-3 activity increases

increased renal tubule apoptosis ( J:156860 )

• after tamoxifen injection, increase in TUNEL+ cells in epithelia

renal/urinary system

increased renal tubule apoptosis ( J:156860 )

• after tamoxifen injection, increase in TUNEL+ cells in epithelia