All Phenotypes Ctnnb1<tm4.1Wbm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctnnb1^tm4.1Wbm
targeted mutation 4.1, Walter Birchmeier
MGI:4429437

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apc^Min/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4429574
cx2	Apc^tm1Tno/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4429576
cx3	Apc^Min/Apc^Min Ctnnb1^tm4.1Wbm/Ctnnb1⁺	involves: 129 * 129P2/OlaHsd * C57BL/6	MGI:4429575

Allelic Composition	Apc^Min/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Ctnnb1^tm4.1Wbm mutation (0 available); any Ctnnb1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Anterior head defects during embryonic development in Apc^Min/Apc^tm1Tno embryos and rescue of head defects by Ctnnb1^tm4.1Wbm/Ctnnb1⁺

liver/biliary system

increased hepatocellular carcinoma incidence ( J:156864 )

• hepatocellular carcinomas (HCC) in 47% of mutant mice (n=15), including 20% that showed intestinal comorbidity

• mice only have HCC (n=4) live longer than Apc^min/+ mice

nervous system

nervous system phenotype ( J:156864 )

N	• normal head morphology

craniofacial

craniofacial phenotype ( J:156864 )

N	• normal head morphology

digestive/alimentary system

intestine polyps ( J:156864 )

• reduced tumor multiplicity and incidence, leaving 6 of 15 mice (40%) free of polyps

• the remaining macroscopic lesions are of tubulo-villous structure

• similar size and latency to those observed in age-matched Apc^min/+ mice

neoplasm

increased hepatocellular carcinoma incidence ( J:156864 )

• hepatocellular carcinomas (HCC) in 47% of mutant mice (n=15), including 20% that showed intestinal comorbidity

• mice only have HCC (n=4) live longer than Apc^min/+ mice

Allelic Composition	Apc^tm1Tno/Apc^tm1Tno Ctnnb1^tm4.1Wbm/Ctnnb1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm1Tno mutation (6 available); any Apc mutation (158 available)
Ctnnb1^tm4.1Wbm mutation (0 available); any Ctnnb1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:156864 )

• no mutant mice (n=8) develope hepatocellular carcinomas by 450 days of age

Allelic Composition	Apc^Min/Apc^Min Ctnnb1^tm4.1Wbm/Ctnnb1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (158 available)
Ctnnb1^tm4.1Wbm mutation (0 available); any Ctnnb1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:156864 )

• death immediately after gastrulation

• embryos only detected at embryonic day 4.5 (E4.5) and E5.5 but not at later stages (E6 and E7)

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