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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfr4tm1Axul
targeted mutation 1, Axel Ullrich
MGI:4429449
Summary 5 genotypes


Genotype
MGI:4429450
hm1
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4tm1Axul
Genetic
Background		 B6.129P2-Fgfr4tm1Axul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:156750 )
N
• in MEFs proliferative capacity, life span, and migration are normal
abnormal cell physiology ( J:156750 )
• when infected with an oncogene MEFs transform faster and form more foci




Genotype
MGI:4429451
cx2
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4+
Tg(WapTgfa)215Bri/0
Genetic
Background		 B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156750 )
• significant increase in the percentage of tumor area compared to Tg alone
increased metastatic potential ( J:156750 )
• at 8-months of age an increased number of large lung metastases are seen

integument
increased mammary adenocarcinoma incidence ( J:156750 )
• significant increase in the percentage of tumor area compared to Tg alone

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156750 )
• significant increase in the percentage of tumor area compared to Tg alone




Genotype
MGI:4429452
cx3
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4tm1Axul
Tg(WapTgfa)215Bri/0
Genetic
Background		 B6.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156750 )
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone
increased metastatic potential ( J:156750 )
• a significantly earlier incidence of lung metastases
• at 8-months of age there are more small and large lung metastases

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156750 )
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone

integument
increased mammary adenocarcinoma incidence ( J:156750 )
• an in increase in tumor mass, tumor area and the percentage of tumor area in 6-month-old female compared to Tg alone
• more and larger tumors in 8-month-old female compared to Tg alone
• tumors are visible significantly earlier compared to Tg alone

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:156750




Genotype
MGI:4429453
cx4
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4tm1Axul
Tg(WapTgfa)215Bri/0
Genetic
Background		 FVB.Cg-Fgfr4tm1Axul Tg(WapTgfa)215Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(WapTgfa)215Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:156750 )
• tumors are visible significantly earlier and the percentage of tumor area is increased

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:156750 )
• tumors are visible significantly earlier and the percentage of tumor area is increased

integument
increased mammary adenocarcinoma incidence ( J:156750 )
• tumors are visible significantly earlier and the percentage of tumor area is increased




Genotype
MGI:4429454
cx5
Allelic
Composition		 Fgfr4tm1Axul/Fgfr4tm1Axul
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Axul mutation (0 available); any Fgfr4 mutation (42 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:156750 )
• no difference in tumor size compared to Tg alone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory