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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp3tm6.2Ayr
targeted mutation 6.2, Alexander Y Rudensky
MGI:4430233
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxp3tm6.2Ayr/Foxp3tm6.2Ayr involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:4430238


Genotype
MGI:4430238
hm1
Allelic
Composition		 Foxp3tm6.2Ayr/Foxp3tm6.2Ayr
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm6.2Ayr mutation (0 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased regulatory T cell number ( J:156942 )
• at or after 6 months of age, but not before, the frequency of Foxp3+ Treg cells is significantly decreased among splenocytes
• CFSE labeled Tregs stimulated with anti-CD3 and anti-CD28 with IL2 have a decreased frequency of Foxp3 cells and amount of Foxp3 per cell, whereas wild-type control cells showed expected increases in both

immune system
decreased regulatory T cell number ( J:156942 )
• at or after 6 months of age, but not before, the frequency of Foxp3+ Treg cells is significantly decreased among splenocytes
• CFSE labeled Tregs stimulated with anti-CD3 and anti-CD28 with IL2 have a decreased frequency of Foxp3 cells and amount of Foxp3 per cell, whereas wild-type control cells showed expected increases in both




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory