Phenotypes associated with this allele

• Allele Symbol: Acacb^tm1.1Dejs
• Allele Name: targeted mutation 1.1, David James
• Allele ID: MGI:4430244
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acacb^tm1.1Dejs/Acacb^tm1.1Dejs	B6.Cg-Acacb^tm1.1Dejs	MGI:4430245

Genotype
MGI:4430245

hm1

• Allelic Composition: Acacb^tm1.1Dejs/Acacb^tm1.1Dejs
• Genetic Background: B6.Cg-Acacb^tm1.1Dejs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal aerobic respiration ( J:157000 )

• decrease in malonyl-CoA levels in skeletal and cardiac muscle

increased fatty acid oxidation ( J:157000 )

• increase in fatty acid oxidation in isolated soleus muscle

• increase in whole-body fatty acid oxidation in the dark cycle

growth/size/body

growth/size/body region phenotype ( J:157000 )

N • despite changes in fatty acid oxidation, no changes in body weight or responses to a high fat diet are detected

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:157000 )

N • despite changes in fatty acid oxidation, no change in energy expenditure is detected

abnormal glucose homeostasis ( J:157000 )

• utilization of glucose for lipid synthesis is increased

increased skeletal muscle glycogen level ( J:157000 )

• muscle glycogen stores are elevated

abnormal lipid homeostasis ( J:157000 )

• utilization of glucose for lipid synthesis is increased

increased fatty acid oxidation ( J:157000 )

• increase in fatty acid oxidation in isolated soleus muscle

• increase in whole-body fatty acid oxidation in the dark cycle

muscle

increased skeletal muscle glycogen level ( J:157000 )

• muscle glycogen stores are elevated