Phenotypes associated with this allele

• Allele Symbol: Fgf8^tm1Jyhl
• Allele Name: targeted mutation 1, James Y H Li
• Allele ID: MGI:4430252
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf8^tm1Jyhl/Fgf8^tm1Jyhl	involves: CD-1	MGI:4430254

Genotype
MGI:4430254

hm1

• Allelic Composition: Fgf8^tm1Jyhl/Fgf8^tm1Jyhl
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal cardiogenic mesoderm morphology ( J:135128 )

• the heart mesoderm is evident but severely malformed at E8.5 in 8% of the mutants (2/25)

abnormal mesoderm development ( J:135128 )

• a cell mass of the nascent mesoderm in the posterior region, bulging into the amniotic cavity at E7.5

• few mesodermal cells outside of the primitive streak in the embryonic region at E7.5

absent mesoderm ( J:135128 )

• absent embryonic mesoderm derived structures at E8.5 in 92% of the mutant (23/25)

• normal extraembryonic mesoderm

abnormal neural fold formation ( J:135128 )

• the headfold is evident but severely malformed at E8.5 in 8% of the mutants (2/25)

abnormal primitive streak morphology ( J:135128 )

• mesodermal cells accumulate at the primitive streak at E7.5

abnormal somite development ( J:135128 )

• the somites are evident but severely malformed at E8.5 in 8% of the mutants (2/25)

cardiovascular system

abnormal cardiogenic mesoderm morphology ( J:135128 )

• the heart mesoderm is evident but severely malformed at E8.5 in 8% of the mutants (2/25)