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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gfi1tm1(cre)Gan
targeted mutation 1, Lin Gan
MGI:4430258
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gfi1tm1(cre)Gan/Gfi1+
Rfx3tm2Wrth/Rfx3tm2Wrth 		involves: 129 * 129S7/SvEvBrd MGI:5907529
cn2
 		Gfi1tm1(cre)Gan/Gfi1+
Rfx1tm1.1Wrth/Rfx1tm1.1Wrth
Rfx3tm2Wrth/Rfx3tm2Wrth 		involves: 129 * 129S7/SvEvBrd MGI:5907531
cn3
 		Bmp2tm1Brd/Bmp2tm1.1Mis
Gfi1tm1(cre)Gan/Gfi1+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:4430834
cn4
 		Pkhd1l1tm2c(EUCOMM)Hmgu/Pkhd1l1tm2c(EUCOMM)Hmgu
Gfi1tm1(cre)Gan/Gfi1+ 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N MGI:6379249
cn5
 		Resttm1.1Bban/Rest+
Gfi1tm1(cre)Gan/Gfi1+ 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB/N MGI:6378689
cn6
 		Gfi1tm1(cre)Gan/Gfi1+
Rfx1tm1.1Wrth/Rfx1tm1.1Wrth 		involves: 129S7/SvEvBrd MGI:5907530


Genotype
MGI:5907529
cn1
Allelic
Composition		 Gfi1tm1(cre)Gan/Gfi1+
Rfx3tm2Wrth/Rfx3tm2Wrth
Genetic
Background		 involves: 129 * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Rfx3tm2Wrth mutation (0 available); any Rfx3 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:227631 )
N
• normal hearing thresholds at 3 months of age




Genotype
MGI:5907531
cn2
Allelic
Composition		 Gfi1tm1(cre)Gan/Gfi1+
Rfx1tm1.1Wrth/Rfx1tm1.1Wrth
Rfx3tm2Wrth/Rfx3tm2Wrth
Genetic
Background		 involves: 129 * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Rfx1tm1.1Wrth mutation (0 available); any Rfx1 mutation (46 available)
Rfx3tm2Wrth mutation (0 available); any Rfx3 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal inner hair cell kinocilium morphology ( J:227631 )
• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time
decreased cochlear outer hair cell number ( J:227631 )
• widespread loss of outer hair cells by P15
cochlear inner hair cell degeneration ( J:227631 )
• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90
abnormal cochlear outer hair cell physiology ( J:227631 )
• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15
impaired hearing ( J:227631 )
• rapid progressive hearing loss beginning at P22 with no measurable hearing by 3 months of age
deafness ( J:227631 )
• no measurable hearing by 3 months of age

nervous system
abnormal inner hair cell kinocilium morphology ( J:227631 )
• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time
decreased cochlear outer hair cell number ( J:227631 )
• widespread loss of outer hair cells by P15
cochlear inner hair cell degeneration ( J:227631 )
• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90
abnormal cochlear outer hair cell physiology ( J:227631 )
• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15

cellular
abnormal inner hair cell kinocilium morphology ( J:227631 )
• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time
increased apoptosis ( J:227631 )
• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15




Genotype
MGI:4430834
cn3
Allelic
Composition		 Bmp2tm1Brd/Bmp2tm1.1Mis
Gfi1tm1(cre)Gan/Gfi1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation (0 available); any Bmp2 mutation (27 available)
Bmp2tm1Brd mutation (0 available); any Bmp2 mutation (27 available)
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:156945 )
• a 6.5 dB shift in threshold is detected at 16kHz in 3-6 month-old mice compared to controls; at 9-10 months, hearing thresholds are comparable to controls




Genotype
MGI:6379249
cn4
Allelic
Composition		 Pkhd1l1tm2c(EUCOMM)Hmgu/Pkhd1l1tm2c(EUCOMM)Hmgu
Gfi1tm1(cre)Gan/Gfi1+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Pkhd1l1tm2c(EUCOMM)Hmgu mutation (0 available); any Pkhd1l1 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:280240 )
• no viable homozygotes are produced




Genotype
MGI:6378689
cn5
Allelic
Composition		 Resttm1.1Bban/Rest+
Gfi1tm1(cre)Gan/Gfi1+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Resttm1.1Bban mutation (0 available); any Rest mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear

nervous system




Genotype
MGI:5907530
cn6
Allelic
Composition		 Gfi1tm1(cre)Gan/Gfi1+
Rfx1tm1.1Wrth/Rfx1tm1.1Wrth
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Rfx1tm1.1Wrth mutation (0 available); any Rfx1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:227631 )
N
• normal hearing thresholds at 3 months of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory