Analysis Tools
vision/eye
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• at 35-somite stage (E10.5), lens anlagen is hypotrophic; at 40-somite stage, lens anlagen is no longer observed
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• at 32-somite stage (E10), ventral optic cup morphology is defective; at 30-somite stage, cell proliferation in ventral optic cup is significantly decreased at this stage compared to controls
• at 40-somite stage (E11), ventral optic cup is no longer observed and dorsal optic cup has degenerated
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• by 40-somite stage, stalk is shorter than in controls
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• ventral parts of vesicle are lost or do not grow appropriately at at 32-somite stage (E10), at 35-somite stage (E10.5), and at 40-somite stage (E11)
• at 24-somite stage, increased numbers of apoptotic cells are observed compared to controls
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anophthalmia
(
J:156737
)
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• newborn animals have no eye tissue; phenotype shows complete penetrance
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growth/size/body
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• after the 26-somite stage (E9.75), entire body is smaller than controls
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hearing/vestibular/ear
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• otic vesicle appears almost normal, but cell proliferation is decreased
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nervous system
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• at PO, animals have small forebrain
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• diencephalon is disproportionately hypotrophic
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embryo
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• after the 26-somite stage (E9.75), entire body is smaller than controls
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